Background: Spinal cord injury (SCI) often leads to severe complications which includes non-healing Stage 4 decubitus ulcers due to immobility, impaired sensation, and poor tissue perfusion. These chronic wounds significantly increase patient morbidity and strain healthcare resources, with traditional management often yielding limited success.
Case Presentation: In this study, we present the case of a 26-year-old male with quadriplegia secondary to an incomplete C5-C6 SCI with chronic advanced Stage 4 sacral and Stage 4 bilateral trochanteric pressure ulcers. He was treated with integrative multidisciplinary regimen including Hyperbaric Oxygen Therapy (HBOT), Ozone Therapy, Platelet-Rich Plasma (PRP) therapy, Intravenous (IV) Micronutrient supplementation, deep tissue mobilization, enema-based gut cleansing, structured neurorehabilitation and intrathecal administration of autologous Bone Marrow Derived Mononuclear Cells (BMMNCs).
Results: Clinical progress was evaluated at 4, 10, 13 and 24 months using ASIA, SCIM, FIM, EPUAP, PUSH and SPSSS scores. The patient demonstrated progressive and complete ulcer healing at sacral and Right trochanteric region by 13 months, with PUSH tool 3.0 scores improving from 16 to 0 and 17 to 2 respectively, EPUAP and SPSSS grading indicating complete resolution at both the regions. Functional improvements included enhanced posture, increased sitting tolerance, absence of postural hypotension, and partial independence in daily activities. No adverse effects were reported throughout the intervention period.
Conclusion: This case illustrates the potential benefits of combining multidisciplinary integrative and rehabilitative treatments along with administration of autologous BMMNCs to enhance wound healing and functional recovery in SCI patients with chronic pressure ulcers, offering an effective alternative to conventional wound management strategies.