Abstract

Thyroid cancer is the most common endocrine cancer in the world, with a rising global incidence over the last three decades. Skull metastasis from a differentiated thyroid malignancy is a rare occurrence. An unusual case of papillary carcinoma thyroid metastasizing in bone and brain which obscuring vision in 70-year-old female did not have any apparent primary in thyroid region. All routine investigations were normal. FNAC revealed - Benign Adnexal Tumor which was Radio logically diagnosed as- Benign Vascular lesion. Craniotomy was done and tumor sent for histopathology, revealed Papillary carcinoma Thyroid metastasizing to bone and involving to brain. Patient referred to oncology. Finally, thyroidectomy was done which was radiologically diagnosed as colloid goiter. Histopathology revealed - Follicular variant of papillary carcinoma Thyroid (pT1N0M1). Patient has been kept on radioiodine therapy and three month follow up reveals good response to therapy. Conclusion: The conventional therapy for metastatic PTC includes a total thyroidectomy, removal of resectable metastatic lesions and a supplementation with radioactive iodine (RAI) and/or external beam radiation at the sites of the metastases. This case and our literature review illustrate that skull metastases should be considered in the clinical course of PTC so that appropriate management can be started.