Biostimulators and their Mechanisms of Action

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Abstract
In the skin aging process, both intrinsic alterations, secondary to the loss of cell regeneration capacity resultant from chronological action and extrinsic alterations, mainly caused by the exposure to ultraviolet radiation, can be observed and change the tissue architecture and skin physiological properties. The treatments that restore the collagen production and stimulate fibroblasts to synthesize and organize the extracellular matrix is critical for morphogenesis, angiogenesis and skin healing. Biostimulation is the ability of a polymer to provide cell benefits or tissue response through specific clinical applications. The potential use of products that stimulate the production of collagen, a component that plays a fundamental role in the properties of the extracellular matrix, nowadays represents a promising perspective for the improvement of skin quality and its mechanical properties by introducing a new concept of therapeutic approach when treating changes caused by skin aging. Its clinical effects are due to the stimulation of a desired controlled inflammatory response, which leads to the slow degradation of the material and culminates with the deposition of collagen in the tissue.
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