Abstract

Background: Bullous pemphigoid (BP) is an autoimmune disease characterized by subepidermal blistering. The pathogenesis of the disease is unidentified in most cases. Drugs can trigger BP. We report a series of drug-induced BP. Methods: A prospective study of all patients diagnosed with BP at the dermatology departments of Ibn Rochd university hospital in Casablanca during the period 2018–2021. Results: Eight patients with a mean age of 49 years, were admitted for management of extensive bullous lesions that appeared after various medications. Skin biopsy, direct and indirect immunofluorescence confirmed the diagnosis of BP. The pharmacovigilance investigation showed an I5B4 causality assessment score for all the drugs, interpreted as highly probable. The diagnosis of vaccine-induced BP was made, and the inducing drugs have been discontinued. All the patients had a favorable outcome. Discussion and Conclusion: Precipitating factors, such as vaccines and drugs, could induce or exacerbate BP disease in the context of several predisposing factors. Therefore, unusual characters of BP must search the medication regimen. The differential diagnosis between classic BP and DIBP can prove to be quite difficult because there is no clear clinical criteria and no definite proof for this diagnosis.