Abstract
                                        Background: Acute intestinal perforation as an early complication of Crohn’s disease in Ghana is rare. Crohn’s disease with 
caecal perforation in a 38-year-old male is described in this case report. He presented with right flank pain which eventually 
extended to the hypogastrium. A diagnosis of ruptured appendix was made clinically. Intra-operatively there was a perforation 
on the caecum which was walled-off by the terminal ileum. A right hemicolectomy was performed and Crohn’s disease of the 
caecum with perforation was made after histopathological examination of the bowel specimen.  
Conclusion: The symptoms of CD may mimic many other abdominal conditions for which urgent medical intervention is 
required, and clinicians must consider it as a differential diagnosis in patients with acute abdomen. Early and accurate 
diagnosis with prompt management procedures is required to avoid life-threatening complications. Histopathological 
examination of tissues removed from patients plays a very important role in confirming the clinical diagnosis.