Abstract

Nowadays, oncological patients live many years after the end of oncological treatments, and this permits the observation of a new spectrum of cutaneous side-effects: the late effects. Skin alterations could represent the first sign of many of these late effects. Capillaroscopy could be used to diagnose initial vascular injury. CIPN could be often revealed by skin and skin appendages atrophy and dystrophy. In particular, nails could show neuronal alterations. Endocrine changes could be associated to many skin and skin appendages signs: hypo-or hyper-pigmentation may reveal adrenal disorders, hair and nails alterations may be associated to thyroid dysfunction, necrobiosis lipoidica, telangiectasias and subcutaneous modifications, in particular in fat composition and architecture could be associated to metabolic disorders. Close follow-up and adoption of early risk-reduction strategies could potentially reduce the impact of these sequelae. Skin surveillance could be a great tool for an early diagnosis.