Abstract

Objective: To investigate small breast epithelial Mucin (SBEM) expression difference in mammary tissues and relationship with clinical - pathological features in breast cancer patients in Han, Buyi and Miao ethnic. Methods: In our study, SBEM protein expressions were detected by means of immunohistochemistry in 297 patients diagnosed from 2014 to 2015, including 99 normal breast tissue specimens, 99 cases of breast benign tumor tissue specimens and 99 tissues specimens from breast cancer patients. Each set of tissue specimens contains 33 samples from Han, Miao and Buyi ethnics, respectively. We analyze the expression of SBEM in different mammary tissues in different ethnics and the association of different SBEM expression levels in tissue of breast cancer patients with clinical - pathological features in Han, Miao and Buyi ethnics, respectively. Results: SBEM positive detection rate was no significant difference in the han, miao and buyi ethnic groups in breast cancer tissue, breast benign tumor tissue and normal breast tissue. SBEM expression in breast cancer tumor cells were related to the ki67 in the Han, Miao and Buyi ethnic (P=0.034, 0.027, 0.047), respectively. There was a marked association between the SBEM expression level and lymphatic metastasis (P =0.042, 0.039) in the Han and Miao ethnic, while the same results were not found in the Buyi people (P=0.072). Conclusion: The SBEM positive detection rate was no significant difference in the han, miao and buyi ethnic groups. SBEM was associated with lymphatic metastasis in the Han and Miao ethnic, while no correlation in the Buyi ethnic.